To accept the accord amid the metabolism and estrogenic action of kakkalide and tectoridin, capital isoflavones in the annual of Pueraria thunbergiana (family Leguminosae), these isoflavones and their metabolites by animal abdominal microflora as able-bodied as their estrogenic furnishings were investigated. All animal begrimed specimens metabolized kakkalide and tectoridin. All abandoned kakkalide-hydrolyzing abdominal bacilli aswell anatomize kakkalide and tectoridin to irisolidone and tectorigenin, respectively. When the estrogenic furnishings of kakkalide and tectoridin were compared with those of their metabolites irisolidone and tectorigenin, the metabolites added potently added admeasurement of MCF-7 beef than kakkalide and tectoridin. These metabolites aswell potently induced estrogen-response c-fos and pS2 mRNA expression. These after-effects advance that kakkalide and tectoridin may be metabolized mainly to irisolidone and tectorigenin, respectively, by abdominal microflora in the intestines, and which may be after captivated into the claret area they can accurate their estrogenic effect.
