In this study, we advised the neuroprotective furnishings of asiaticoside, a triterpenoid saponin abandoned from the Chinese alleviative assemble Centella asiatica, in the rats archetypal of Parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Rats were aboriginal injected with MPTP. One day afterwards surgery, asiaticoside was administered and the behavioral tests were assessed. On 14th day, the rats were sacrificed, substantia nigra (SN) and striatum were dissected, and again dopamine (DA) and its metabolites in striatum and malonyldialdehyde (MDA) contents, bargain glutathione (GSH) akin and gene announcement akin in SN were estimated. Treatment with asiaticoside was begin to assure dopaminergic neuron by antagonizing MPTP induced neurotoxicity and to advance locomotor dysfunction. Asiaticoside decidedly attenuated the MPTP-induced abridgement of dopamine in the striatum. The agreeable of MDA was decidedly decreased while the GSH akin was decidedly added in asiaticoside-treated groups. In addition, asiaticoside added the Bcl-2/Bax ratio. These after-effects adumbrated that asiaticoside was able in abandoning MPTP induced Parkinsonism via its neuroprotective furnishings including antioxidant activity, advancement the metabolic antithesis of DA, and accretion arrangement of Bcl-2/Bax.
