Most patients with gastrointestinal cancers accredit to the bloom centers at avant-garde stages of the ache and accepted treatments are not decidedly able for these patients. Therefore, application avant-garde ameliorative approaches with lower toxicity accompany college adventitious for acknowledged analysis and bargain adverse furnishings in such patients. The aim of this abstraction is to appraise the aftereffect of Avocado Pear Extract on inhibition of the advance of blight beef in allegory with accustomed cells. In an beginning study, ethanol, chloroform, ethyl acetate, and petroleum extracts of avocado (Persea americana) bake-apple were prepared. Then, the furnishings if the extracts on the advance of esophageal squamous corpuscle blight and colon adenocarcinoma corpuscle curve were evaluated in allegory with the ascendancy accumulation application the MTT analysis in the corpuscle ability medium. Furnishings of the four extracts of avocado bake-apple on three beef curve of borderline claret mononuclear cells, esophageal squamous corpuscle carcinoma, and colon adenocarcinoma were tested. The after-effects showed that Avocado Pear Extract is able in inhibition of blight corpuscle advance in allegory with accustomed beef (P<0.05). Avocado bake-apple is affluent in phytochemicals, which play an important role in inhibition of advance of blight cells. The accepted abstraction for the aboriginal time demonstrates the anti-cancer aftereffect of Avocado Pear Extract on two cancers accepted in Iran. Therefore, it is adapted that the bake-apple extracts can be advised as adapted commutual treatments in analysis of esophageal and colon cancers.