Stress is a key account of affair bistro (BE). Since Rhodiola rosea is accepted to attune accent responses, its aftereffect in a archetypal of BE was investigated. BE for awful acceptable aliment (HPF) was evoked in changeable rats by three 8-day cycles of aliment restriction/re-feeding (for 4days 66% of the accepted chow intake; for 4days aliment ad libitum) and astute accent on the analysis day (day 25). R. rosea dry abstract (3% rosavin, 3.12% salidroside) or its alive attempt were accustomed by gavage 1h afore admission to HPF. Only rats apparent to both aliment restrictions and accent apparent BE in the aboriginal 15-60min afterwards the demanding procedure. R. rosea abstract 10mg/kg decidedly bargain and 20mg/kg abolished the BE episode. R. rosea abstract 20mg/kg abolished aswell stress-induced access in serum corticosterone levels. The R. rosea alive assumption salidroside, but not rosavin, at doses present in the extract, dose-dependently bargain or abolished BE for the aeon in which it was elicited. In cessation after-effects announce that R. rosea extracts may accept ameliorative backdrop in bingeing-related bistro disorders and that salidroside is the alive assumption amenable for this effect.
