Postmenopausal cartilage accident and the accessible progression to osteoporosis are a above bloom concern. Mushrooms accept been accustomed as anatomic foods. Pleurotus Eryngii Extract has been appear to accept estrogenic activity, suggesting that its burning may abate postmenopausal cartilage loss. The aim of the present abstraction was to actuate the aftereffect of supplementation with an booze abstract of P. eryngii on cartilage metabolism in a postmenopausal osteoporosis rat model. Female 12-week-old Wistar rats were subjected to either adulterated operation or mutual ovariectomy. The ovariectomized rats were afresh subdivided into two groups: one fed the abstract and the added not. Twelve weeks afterwards surgery, indices of cartilage mass, cartilage histomorphometry, and cartilage mechanics were measured. The appropriate femur cartilage mineral agreeable and body of the ovariectomized accumulation were decidedly lower than in the Adulterated group, and abstract supplementation did not accept any cogent aftereffect on these differences. Furthermore, ovariectomy decidedly added measures of mineralizing apparent and cartilage accumulation rates; again, abstract supplementation afresh had no cogent effect.