Asiatic acid, madecassic acid, and asiaticoside, terpenoids with an ursane skeleton, were activated alone and in aggregate on derma animal fibroblast collagen I amalgam in vitro. In the absence of ascorbic acid, the admixture as able-bodied as anniversary alone basic angry collagen I amalgam to a agnate extent. In the attendance of ascorbic acid, the akin of collagen I beard was college for anniversary alone basic and for the mixture. A allegory of asiaticoside and asiatic acerbic shows that the amoroso atom of the atom does not assume to be all-important for this biological activity.
