Amentoflavone is a biflavonoid (bis-apigenin accompanying at 8 and 3' positions, or 3′,8′′-biapigenin) basic of a amount of plants including Ginkgo biloba, Chamaecyparis obtusa (hinoki), Hypericum perforatum (St. John’s Wort) and Xerophyta plicata. Amentoflavone can collaborate with abounding medications by getting a almighty inhibitor of CYP3A4 and CYP2C9, which are enzymes amenable for the metabolism of some drugs in the body.It is aswell an inhibitor of animal cathepsin B. Amentoflavone has a array of in vitro activities including antimalarial activity,anticancer action (which may, at atomic in part, be advised by its inhibition of blubbery acerbic synthase), and adversary action at the κ-opioid receptor (Ke = 490 nM) as able-bodied as action at the allosteric benzodiazepine website of the GABAA receptor as a abrogating allosteric modulator.
