Antioxidant activity of costunolide and eremanthin isolated fromCostus speciosus Sm

  Antioxidant backdrop of abounding alleviative plants accept been broadly accustomed and some of them accept been commercially exploited. Bulb acquired antioxidants play a actual important role in abating problems accompanying to oxidative stress.
  The present abstraction was aimed at assessing the antioxidant acreage of costunolide and eremanthin abandoned from a alleviative bulb Costus speciosus (Koen ex. Retz) Sm. rhizome. Experimental diabetes was induced by a individual dosage of STZ (60 mg/kg, i.p.) injection. The oxidative accent was abstinent by tissue thiobarbituric acerbic acknowledging substances (TBARS), bargain glutathione (GSH) agreeable and enzymatic activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) in brain, liver, heart, branch and pancreas. An access in TBARS level, a cogent abridgement in GSH agreeable forth with decreased enzymatic activities of SOD, CAT, and GPx were apparent in basic diabetic rats.
  Administration of either costunolide (20 mg/kg day) or eremanthin (20 mg/kg day) for 60 canicule acquired a cogent abridgement in TBARS akin and a cogent access in GSH agreeable forth with added enzymatic activities of SOD, CAT and GPx in the advised rats if compared to basic diabetic rats. Acute toxicity analysis appear the non-toxic attributes of the compounds. The after-effects adumbrated for the aboriginal time the careful aftereffect of costunolide and eremanthin from oxidative stress, appropriately aperture the way for their use in medication.