One of the keys for auspiciously developing drugs adjoin the ample spectrum of blight corpuscle types is structural diversity. In the accepted study, we focused on a ancestors of isosteviol derivatives as abeyant atypical antitumor agents.
Isosteviol is a tetracyclic diterpenoid acquired by acerbic hydrolysis of steviol glycoside extracts abandoned from abounding Stevia rebaudiana plants. In this work, we accept advised and actinic a console of isosteviol triazole conjugates application 'click' allure methodology. Evaluation of these compounds adjoin a alternation of blight corpuscle curve acquired from primary and metastatic tumors approved that these conjugates display cytotoxic activities with IC50 in the low μM range.
In addition, their anti-proliferative activities are blight corpuscle blazon specific. Taken together, our studies accentuate the accent of structural assortment in accomplishing blight corpuscle blazon specific biologic development.
